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13C NMR spectroscopy of some third-generation cephalosporins, their synthetic intermediaries and reaction byproducts
Authors:López Miguel A  Rodríguez Zalua  González Maritza  Tolón Blanca  Avila Rizette  Rodríguez Juan C  Vélez-Castro Hermán  Fini Adamo
Affiliation:Centro de Química Farmacéutica, Avenida 200 y 21, Siboney, Playa, CP 16042, Ciudad de La Habana, Cuba.
Abstract:(13)C NMR spectroscopic data for 25 cephalosporin derivatives were assigned by combination of one- and two-dimensional experiments. The effect of the substitution at C-3, C-7 and C-4 acid group positions on the chemical shifts of the cephem nucleus is discussed.
Keywords:NMR  13C NMR  chemical shifts  cephalosporins
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