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Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving-bed chromatography |
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| Authors: | O'Brien Alexander G Horváth Zoltán Lévesque François Lee Ju Weon Seidel-Morgenstern Andreas Seeberger Peter H |
| Affiliation: | Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Potsdam, Germany. |
| Abstract: | Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desired monosubstituted product can be continuously separated from the byproducts in a purity of over 99 % by coupling a flow reactor to a simulated moving bed (SMB) chromatography module. |
| Keywords: | continuous synthesis flow chemistry nucleophilic aromatic substitution purification simulated moving‐bed chromatography |
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