Synthesis of 3-substituted isocoumarins via a cascade intramolecular Ullmann-type coupling-rearrangement process |
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Authors: | Ge Zhi-Yuan Fei Xiang-Dong Tang Ting Zhu Yong-Ming Shen Jing-Kang |
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Institution: | College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, People's Republic of China. |
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Abstract: | A simple and highly efficient strategy for the synthesis of 3-substituted isocoumarins through a copper(I)-catalyzed reaction of 1-(2-halophenyl)-1,3-diones has been developed. The procedure is based on a cascade copper-catalyzed intramolecular Ullmann-type C-arylation and rearrangement process. This methodology is tolerant of a wide range of substrates and applicable to library synthesis. |
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