Multifunctional Fe3O4/TaO(x) core/shell nanoparticles for simultaneous magnetic resonance imaging and X-ray computed tomography |
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| Authors: | Lee Nohyun Cho Hye Rim Oh Myoung Hwan Lee Soo Hong Kim Kangmin Kim Byung Hyo Shin Kwangsoo Ahn Tae-Young Choi Jin Woo Kim Young-Woon Choi Seung Hong Hyeon Taeghwan |
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| Institution: | World Class University Program of Chemical Convergence for Energy & Environment, Institute of Chemical Processes, and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea. |
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| Abstract: | Multimodal imaging is highly desirable for accurate diagnosis because it can provide complementary information from each imaging modality. In this study, a sol-gel reaction of tantalum(V) ethoxide in a microemulsion containing Fe(3)O(4) nanoparticles (NPs) was used to synthesize multifunctional Fe(3)O(4)/TaO(x) core/shell NPs, which were biocompatible and exhibited a prolonged circulation time. When the NPs were intravenously injected, the tumor-associated vessel was observed using computed tomography (CT), and magnetic resonance imaging (MRI) revealed the high and low vascular regions of the tumor. |
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