Enantio- and diastereoselective hydrogenation via dynamic kinetic resolution by a cationic iridium complex in the synthesis of beta-hydroxy-alpha-amino acid esters |
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| Authors: | Makino Kazuishi Iwasaki Masamichi Hamada Yasumasa |
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| Institution: | Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. |
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| Abstract: | Anti-selective asymmetric hydrogenation of alpha-amino-beta-keto esters via dynamic kinetic resolution under low hydrogen pressure has been achieved by an easily-handled cationic iridium complex with tetrakis3,5-bis(trifluoromethyl)phenyl]borate (BARF) as a counterion. |
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