Palladium-catalyzed direct arylation of imidazolone N-oxides with aryl bromides and its application in the synthesis of GSK2137305 |
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| Authors: | Zhao He Wang Ruifang Chen Ping Gregg Brian T Hsia Ming Min Zhang Wei |
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| Affiliation: | Medicinal Chemistry Department, AMRI, 26 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098, USA. He.Zhao@amriglobal.com |
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| Abstract: | The palladium-catalyzed direct arylation of imidazolone N-oxides with aryl bromides to afford the corresponding 4-aryl imidazolone N-oxides is described. This method has been successfully used for the synthesis of GSK2137305. |
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