Direct enantiomeric separations of tris(2-phenylpyridine) iridium (III) complexes on polysaccharide derivative-based chiral stationary phases |
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Authors: | Chen Xiaoming Okamoto Yoshio Yano Tomohiro Otsuki Joe |
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Institution: | EcoTopia Science Institute, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Japan. |
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Abstract: | A convenient method is presented for the first time for the direct separation of enantiomers of a tris(2-phenylpyridine) iridium (III) and an analog substituted with long alkoxy chains on polysaccharide derivative-based chiral stationary phases by HPLC. Tris(2-phenylpyridine) iridium (III) was separated on the immobilized amylose 3,5-dimethylphenylcarbamate (Chiralpak IA) using hexane/CHCl3/CH2Cl2 (75:20:5) as an eluent, and the analog could be separated on the coated cellulose 3,5-dimethyl-phenylcarbamate (Chiralcel OD) and cellulose 4-methylbenzoate (Chiralcel OJ) using hexane/2-propanol (96:4) as the eluent. CD spectra of the eluted HPLC fractions were also recorded, and the observed mirror image patterns confirm their enantioseparations. |
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Keywords: | Chiral separation Chiral stationary phase HPLC Polysaccharide derivative Tris(2‐phenylpyridine) iridium (III) complexes |
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