| Abstract: | The title compound, (5R,9R,13S,14S,17R)‐14‐hydroxy‐3‐methoxy‐17‐methyl‐4,5‐epoxymorphinan‐6‐one N‐oxide, C18H21NO5, has been prepared in a diastereomerically pure form by the reaction of oxycodone with 3‐chloroperbenzoic acid and subsequent crystallization of the product from chloroform. The crystal packing shows that the molecule exhibits intramolecular O—H...O D...A = 2.482 (2) Å] hydrogen bonding. In addition, there are weak intermolecular C—H...O interactions which, along with van der Waals forces, stabilize the structure. The new chiral center at the 17‐position is demonstrated to be R. |
