| 固相萃取/离子阱气相色谱质谱联用对血液中多种安眠药物的同时测定 |
| |
| 引用本文： | 陈建虎.固相萃取/离子阱气相色谱质谱联用对血液中多种安眠药物的同时测定[J].分析测试学报,2010,29(1). |
| |
| 作者姓名： | 陈建虎 |
| |
| 作者单位： | 新疆生产建设兵团公安局,物证鉴定中心,新疆,乌鲁木齐,830002 |
| |
| 摘 要： | 建立了气相色谱-质谱联用测定血液中多种安眠药物的分析方法,通过固相萃取提取并富集血液样品中的9种常见巴比妥类、吩噻嗪类和苯二氮杂类安眠药物,采用离子阱二级质谱检测其含量。通过优化萃取溶液pH值及气相色谱-质谱联用分析条件,对9种安眠药物进行了定量分析。采用离子阱串联质谱(MS/MS)技术消除基底干扰,给出被测物结构信息。9种安眠药物的检出限为0.04~0.10 mg/L,回收率为78%~93%。方法用于人心血中安眠药物的检测,检出安定0.6 mg/L。该方法高效、简单、灵敏度高,可用于血液中巴比妥类、吩噻嗪类和苯二氮杂类安眠药物的同时测定。
|
| 关 键 词： | 固相萃取 气相色谱质谱联用 血液 安眠药物 |
Simultaneously Determination of Various Hypnotics in Human Blood by Solid-phase Extraction/Ion Trap Gas Chromatography-Mass Spectrometry |
| |
| CHEN Jian-hu.Simultaneously Determination of Various Hypnotics in Human Blood by Solid-phase Extraction/Ion Trap Gas Chromatography-Mass Spectrometry[J].Journal of Instrumental Analysis,2010,29(1). |
| |
| Authors: | CHEN Jian-hu |
| |
| Institution: | CHEN Jian-hu(Institute of Forensic,Public Security Bureau of Xinjiang Production , Construction Corps,Urumchi 830002,China) |
| |
| Abstract: | A qualitative and quantitative analysis method was developed for determination of 9 hypnotics including barbiturates,phenothiazines and benzodiazepines by solid-phase extraction/ion trap gas chromatography-mass spectrometry.9 hypnotics in human blood were extracted and enriched by solid-phase extraction.The separation and quantitative analysis of 9 hypnotics was performed by ion trap gas chromatography-tandem mass spectrometry.pH values of extraction solution was optimized,and separation and detection condi... |
| |
| Keywords: | solid-phase extraction gas chromatography-mass spectrometry blood hypnotics |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
