Versatile Nitro-Fluorophore as Highly Effective Sensor for Hypoxic Tumor Cells: Design, Imaging and Evaluation |
| |
Authors: | Min Dai Weiping Zhu Yufang Xu Xuhong Qian Yan Liu Yi Xiao Yin You |
| |
Institution: | (1) Shanghai Key Lab. Chem. Biology, East China University of Science and Technology, Shanghai, 200237, China;(2) State Key Lab. Fine Chemicals, Dalian University of Technology, Dalian, 116012, China;(3) Shanghai Key Lab of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China |
| |
Abstract: | Based on the characteristics of a nitro-group, which can be partially or totally reduced to an amino-group in hypoxic cells,
two series of hypoxic sensors containing 7H-Benzimidazole 2,1-a]benzde]isoquinolin-7-one cores with nitro groups in different
positions were designed, synthesized and evaluated. The target compounds exhibited significantly different fluorescence characteristics
(fluorescence enhancement or quenching). The strong fluorescences of some partially reduced compounds could be explained through
the examination of their infrared spectra, which showed a restriction of the nitro-group vibration. These compounds exhibited
significant hypoxic–oxic fluorescence differences not only in numerical values but also in their fluorescent imaging properties
as reported for the first time.
|
| |
Keywords: | Nitro-fluorophore Sensor Hypoxic Tumor cell |
本文献已被 PubMed SpringerLink 等数据库收录! |
|