A general synthetic approach to the amnesic shellfish toxins: total synthesis of (-)-isodomoic acid B, (-)-isodomoic acid E and (-)-isodomoic acid F |
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Authors: | Lemière Gilles Sedehizadeh Simon Toueg Julie Fleary-Roberts Nadia Clayden Jonathan |
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Affiliation: | School of Chemistry, University of Manchester, Oxford Rd., Manchester M13 9PL, UK. |
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Abstract: | The alkynylpyrrolidine 4 was made via a dearomatising cyclisation of an aromatic amide, and was elaborated by stannylcupration and palladium-catalysed coupling to achieve the first total synthesis of three members of the isodomoic acid family; the same alkyne can be envisaged as a precursor to several more of this class of amnesic shellfish toxins. |
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