1. Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184‐8588 (Japan), Fax: (+81)?42‐388‐7034;2. Instrumentation Analysis Center, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184‐8588 (Japan)
Abstract:
A route with less congestion : A practical method for the highly diastereoselective preparation of anti tertiary homoallylic alcohols has been developed. The reaction of allyltitanocenes, generated by the reductive titanation of various allylic substrates with a titanocene(II) species, with a variety of ketones produced the anti tertiary homoallylic alcohols in good diastereoselectivity, even when using sterically less congested ketones (see scheme; Cp: cyclopentadienyl; Piv: pivaloyl).
