|
|||||
|
|
Design,Synthesis, and Biological Evaluation of Artificial Macrosphelides in the Search for New Apoptosis‐Inducing Agents |
|
| Authors: | Yuji Matsuya Dr Yuta Kobayashi Takanori Kawaguchi Ayana Hori Yuka Watanabe Kentaro Ishihara Kanwal Ahmed Zheng‐Li Wei Da‐Yong Yu Qing‐Li Zhao Takashi Kondo Prof?Dr Hideo Nemoto Prof?Dr |
| Institution: | Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930‐0194 (Japan), Fax: (+81)?76‐434‐5047 |
| Abstract: | A drug of two halves : New artificial compounds composed of a macrosphelide core skeleton and an epothilone side chain were designed and synthesized. These compounds were more potent inducers of apoptosis than the parent natural‐type macrosphelides.  |
| Keywords: | anticancer agents apoptosis epothilones macrosphelides metathesis |