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para‐Functionalized Aryl‐di‐tert‐butylfluorosilanes as Potential Labeling Synthons for 18F Radiopharmaceuticals |
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| Authors: | Ljuba Iovkova Dipl. Chem. Björn Wängler Dr. Esther Schirrmacher Dr. Ralf Schirrmacher Prof. Dr. Gabriele Quandt Dipl. Chem. Guido Boening Dr. Markus Schürmann Klaus Jurkschat Prof. Dr. |
| Affiliation: | 1. Lehrstuhl für Anorganische Chemie II, Technische Universit?t Dortmund, 44221 Dortmund (Germany);2. Klinik und Poliklinik für Nuklearmedizin, Ludwig‐Maximilians‐Universit?t München, 81377 München (Germany);3. Lady Davis Institute for Medical Research, McGill University, Jewish General Hospital, 3755, Chemin de la C?te St. Catherine, Montreal, QC (Canada);4. McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3800 University Street, Montreal, QC (Canada) |
| Abstract: | Broad spectrum : Novel para‐functionalized aryl‐di‐tert‐butylfluorosilanes, p‐(tBu2FSi)C6H4X (X=functional group), have been made available and broaden the spectrum of silicon‐based 18F acceptors (SiFAs) for potential PET applications. For example, the [18F]maleimido derivative 1 has been employed for the synthesis of [18F] 1 ‐ labeled rat serum albumin (RSA), the applicability of which for PET has been verified by in vivo experiments.  |
| Keywords: | fluorine isotopic labeling positron emission tomography radiopharmaceuticals silicon X‐ray diffraction |