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DNA Cross‐Linking Patterns Induced by an Antitumor‐Active Trinuclear Platinum Complex and Comparison with Its Dinuclear Analogue |
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| Authors: | Jianhui Zhu Yongmei Zhao Dr Yanyan Zhu Ziyi Wu Miaoxin Lin Weijiang He Dr Yan Wang Dr Guangju Chen Prof?Dr Lei Dong Dr Junfeng Zhang Prof?Dr Yi Lu Prof?Dr Zijian Guo Prof?Dr |
| Institution: | 1. State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (China), Fax: (+86)?25‐8322?4539;2. College of Chemistry, Beijing Normal University, Beijing 100875 (China);3. State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093 (China);4. Department of Chemistry, University of Illinois at Urbana‐Champaign, Urbana, Illinois 61801 (USA) |
| Abstract: | The center of it all : An antitumor‐active trinuclear platinum complex forms unprecedented interstrand cross‐linked triadducts with 18‐mer DNA duplexes (see figure; complex in yellow with the platinum centers in red) and behaves differently from its dinuclear analogue.  |
| Keywords: | antitumor agents DNA structures mass spectrometry molecular modeling platinum |