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Synthesis and Structure of α/δ‐Hybrid Peptides—Access to Novel Helix Patterns in Foldamers |
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| Authors: | Gangavaram V?M Sharma Dr Bommagani Shoban Babu Kallaganti V?S Ramakrishna Pendem Nagendar Dr Ajit C Kunwar Dr Peter Schramm Carsten Baldauf Dr Hans‐Jörg Hofmann Prof Dr |
| Institution: | 1. D‐211, Discovery Laboratory, Organic Chemistry Division III, Indian Institute of Chemical Technology, Hyderabad 500 007 (India);2. NMR Group, Indian Institute of Chemical Technology, Hyderabad 500 007 (India);3. Institute of Biochemistry, Faculty of Biosciences, University of Leipzig, Brüderstra?e 34, 04103 Leipzig (Germany);4. Structural Bioinformatics, Biotechnology Center, Technical University Dresden, Tatzberg 47‐51, 01307 Dresden (Germany) |
| Abstract: | Origami peptides : A novel class of foldamers consisting of α/δ‐hybrid peptides has been investigated theoretically and experimentally by exploiting the rigidity of the side chain of a new δ‐amino acid prepared from D ‐glucose and D ‐xylose with a furanose side chain (see figure).  |
| Keywords: | ab initio calculations amino acids foldamers mixed helices peptides |