1. Institut de Chimie des Substances Naturelles du CNRS, Avenue de la Terrasse, 91198 Gif‐sur‐Yvette (France);2. Université Paris‐Sud 11, Institut de Chimie Moléculaire et des Matériaux associé au CNRS, 91405 Orsay Cedex (France), Fax: (+33)?1‐6985‐3715
Abstract:
A regio‐ and stereocontrolled solution for a selective modification at the C‐2 or C‐4 position of N‐acetylneuraminic acid involves the use of allylic substitution catalyzed by palladium. As illustrated in the scheme, regioselective malonylation is under the strict influence of the ligands associated with the allylpalladium complex.
