Direct Oxidation of β‐Aryl Substituted Aldehydes to α,β‐Unsaturated Aldehydes Promoted by an o‐Anisidine–Pd(OAc)2 Co‐catalyst |
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| Authors: | Jie Liu Jin Zhu Dr Hualiang Jiang Prof?Dr Wei Wang Prof?Dr Jian Li Prof?Dr |
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| Institution: | 1. School of Pharmacy, East China University of Science & Technology, 130 Meilong road, Shanghai 200237 (P.R. China), Fax: (+86)?21‐64252584;2. Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203 (P.R. China);3. Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131‐0001 (USA), Fax: (+1)?505‐277‐2609 |
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| Abstract: | An o‐anisidine‐Pd(OAc)2 catalytic system for the direct co‐catalytic Saegusa oxidation of β‐aryl substituted aldehydes to α,β‐unsaturated aldehydes has been developed. The use of o‐anisidine in place of (S)‐diphenylprolinol made the process more simply and cost‐effective. The process not only features the use of unmodified aldehydes rather than enol silyl ethers, but also gives moderate to good yields (44–72 %). |
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| Keywords: | aldehydes anisidine organocatalysis palladium Saegusa reaction |
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