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Low‐Molecular‐Weight Dendrons for DNA Binding and Release by Reduction‐Triggered Degradation of Multivalent Interactions |
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| Authors: | Mauri A. Kostiainen Dr. Henna Rosilo |
| Affiliation: | 1. Department of Engineering Physics, Helsinki University of Technology, P.O. BOX 2200, 02015 HUT, Espoo (Finland), Fax: (+358)?9‐451‐3155;2. Current Address: Institute for Molecules and Materials, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen (The Netherlands) |
| Abstract: | Losing the grip : The synthesis of multivalent low‐molecular‐weight dendrons with lysine branching units coupled to disulfide‐linked spermine surface groups is described. It is furthermore demonstrated that the dendrons bind DNA with good affinity (see image), but are also able to release the DNA in a reductive environment.  |
| Keywords: | dendrimers DNA multivalency self‐assembly triggered release |