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Zinc and Cadmium Complexes of a Plant Metallothionein under Radical Stress: Desulfurisation Reactions Associated with the Formation of trans‐Lipids in Model Membranes |
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| Authors: | Armida Torreggiani Dr Jordi Domènech Dr Ruben Orihuela Dr Carla Ferreri Dr Sílvia Atrian Prof Mercè Capdevila Prof Chryssostomos Chatgilialoglu Dr |
| Institution: | 1. ISOF, Consiglio Nazionale delle Ricerche, Via P. Gobetti 101, 40129 Bologna (Italy), Fax: (+39)?051‐639‐8349;2. Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Av. Diagonal 645, 08028 Barcelona (Spain);3. Departament de Química, Facultat de Ciències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona (Spain);4. Institut de Biomedicina de la Universitat de Barcelona (IBUB) (Spain) |
| Abstract: | Biomimetic tandem protein/lipid damage : The reactions of reductive reactive species, produced by γ irradiation of water, with Zn and Cd complexes of a metallothionein from a plant afford diffusible sulfur‐centred radicals generated from methionine residues and sulfide ligands. These species migrate from the aqueous phase to the lipid bilayer and transform the cis double bond of the oleate moiety to trans isomer (see scheme).  |
| Keywords: | biomimetic chemistry liposomes metalloproteins radical reactions reaction mechanisms |