Instituto de Química Molecular Aplicada, Universidad Politécnica de Valencia, Camino de Vera s/n, 46022 Valencia (Spain), Fax: (+34)?96‐387‐9349
Abstract:
Heparin detective : Silica nanoparticles functionalised with ion‐channel scaffolds were prepared and used for the chromofluorogenic sensing of heparin in aqueous environments (see figure). The surface of the nanoparticles was functionalised with polyamines (binding sites) and thiols. The reaction of a dye (squaraine) with the surface thiol groups was selectively inhibited by the coordination of heparin with the partly protonated polyamines.
