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Rhodium(I)‐Catalysed Intramolecular [2+2+2] Cyclotrimerisations of 15‐, 20‐ and 25‐Membered Azamacrocycles: Experimental and Theoretical Mechanistic Studies |
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| Authors: | Anna Dachs Anna Torrent Anna Roglans Dr Teodor Parella Dr Sílvia Osuna Miquel Solà Prof |
| Institution: | 1. Institut de Química Computacional and Departament de Química, Universitat de Girona, Campus de Montilivi, 17071 Girona (Spain), Fax: (+34)?972‐418‐356;2. Departament de Química, Universitat de Girona, Campus de Montilivi, 17071 Girona (Spain), Fax: (+34)?972‐418‐150;3. Servei de RMN, Universitat Autònoma de Barcelona, Cerdanyola, 08193 Barcelona (Spain) |
| Abstract: | Number of members makes a difference : The 2+2+2] intramolecular cyclotrimerisation of a new series of 20‐ and 25‐membered azamacrocycles catalysed by the Wilkinson's catalyst are reported (see scheme). The 20‐ and 25‐membered azamacrocycles show different reactivity. Why? Theoretical calculations give insight into the reactivity differences observed for the 20‐ and 25‐membered macrocycles.  |
| Keywords: | cyclotrimerization density functional calculations macrocycles reaction mechanisms rhodium |