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Asymmetric Syntheses and Wnt Signal Inhibitory Activity of Melleumin A and Four Analogues of Melleumins A and B |
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| Authors: | Jie‐Min Luo Chao‐Feng Dai Dr Shu‐Yong Lin Pei‐Qiang Huang Prof Dr |
| Institution: | 1. Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005 (China), Fax: (+86)?592‐2186400;2. School of Life Science, Xiamen University, Xiamen, Fujian 361005 (China) |
| Abstract: | Guided by nature : A flexible and epimerization‐free approach for the asymmetric syntheses of melleumin A and four analogues of melleumins A and B was developed, which allowed confirming the stereochemistry at C‐4 of melleumin A, and revealed that the unnatural 4‐epi‐melleumin B possesses a modest inhibitory activity on Wnt signaling.  |
| Keywords: | asymmetric synthesis biological activity natural products total synthesis Wnt signal inhibition |