Bioactive Hydrogel Layers on Microdisk Electrode Arrays: Cyclic Voltammetry Experiments and Simulations |
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| Authors: | Gusphyl Justin Abdur Rub Abdur Rahman Anthony Guiseppi‐Elie |
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| Affiliation: | 1. Center for Bioelectronics, Biosensors and Biochips (C3B), Clemson University, 100 Technology Drive, Anderson, South Carolina 29625, USA;2. Department of Chemical and Biomolecular Engineering, Clemson University, Clemson, South Carolina 29634, USA;3. Department of Bioengineering, Clemson University, Clemson, South Carolina 29634, USA |
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| Abstract: | Poly(hydroxyethylmethacrylate)‐based hydrogel membranes were applied to microfabricated, microdisk electrode arrays (MDEAs) of 50 μm (5184 disks), 100 μm (1296 disks) and 250 μm (207 disks) (d/r=4; A= 0.1 cm2) and studied by cyclic voltammetry (CV) in 1.0 mM ferrocene monocarboxylic acid (FcCO2H). The membrane produced an order of magnitude decrease in current densities and a shift to quasi reversibility due to a decrease in the Dappt of FcCO2H, from 4.51×10?6 cm2 s?1 to 1.42×10?8 cm2 s?1, (2.18×10?8 cm2 s?1 from release experiments). The MDEA050 (comprising 50 μm disks) maintained its enhanced current density attributes confirming its value as an effective electrode for biosensors. Finite element modeling (FEM) simulations successfully replicated the voltammograms of the MDEAs. |
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| Keywords: | Hydrogels Microdisk arrays Cyclic voltammetry Biosensors Simulation |
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