Cobalt‐Catalyzed Isomerization of 1‐Alkenes to (E)‐2‐Alkenes with Dimethylphenylsilylmethylmagnesium Chloride and Its Application to the Stereoselective Synthesis of (E)‐Alkenylsilanes
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto‐daigaku Katsura, Nishikyo, Kyoto 615‐8510 (Japan), Fax: (+81)?75‐383‐2438
Abstract:
“Co”axing selectivity into isomerization : Treatment of 1‐alkenes with dimethylphenylsilylmethylmagnesium chloride in the presence of a cobalt‐NHC complex in dioxane at 50 °C or higher provides the corresponding (E)‐2‐alkenes selectively. The isomerization is applicable to the stereoselective synthesis of (E)‐crotylsilanes and (E)‐1‐propenylsilanes from the corresponding homoallylsilanes and allylsilanes, respectively.
