School of Chemistry, University of Hyderabad, Hyderabad 500046 (India), Fax: (+91)?40‐23012460
Abstract:
A practical and sustainable chemical process for the synthesis of highly substituted aldol?lactol products was achieved for the first time through the asymmetric Barbas–List aldol (BLA) reaction of 2‐hydroxybenzaldehydes with acetone in the presence of a catalytic amount of trans‐4‐OH‐L ‐proline (see scheme).
