Toward Efficient Palladium‐Catalyzed Allylic C?H Alkylation |
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| Authors: | Thomas Jensen Peter Fristrup Dr. |
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| Affiliation: | Department of Chemistry, Technical University of Denmark, Kemitorvet, building 207 (Denmark), Fax: (+45)?45‐88‐3136 |
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| Abstract: | Recent breakthroughs have proved that direct palladium(II)‐catalyzed allylic C? H alkylation can be achieved. This new procedure shows that the inherent requirement for a leaving group in the Tsuji–Trost palladium‐catalyzed allylic alkylation can be lifted. These initial reports hold great promise for the development of allylic C? H alkylation into a widely applicable methodology, thus providing a means to enhance synthetic efficiency in these reactions. |
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| Keywords: | allylic alkylation C?H activation homogeneous catalysis palladium |
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