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Facile and Efficient Enantioselective Strecker Reaction of Ketimines by Chiral Sodium Phosphate
Authors:Ke Shen  Xiaohua Liu  Yunfei Cai  Lili Lin  Xiaoming Feng Prof?Dr
Institution:Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (P.R. China), Fax: (+86)?28‐8541‐8249
Abstract:Asymmetric catalysis : A facile enantioselective Strecker reaction of ketimines with trimethylsilyl cyanide (TMSCN) was realized by employing chiral (S)‐BNPNa 3 e and PBAP as an additive (see image). A wide substrate scope and good‐to‐excellent enantioselectivities were achieved.
image

Keywords:asymmetric catalysis  enantioselectivity  ketimines  sodium  Strecker reaction
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