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Solid‐State Structural Characterization of Cutinase–ECE‐Pincer–Metal Hybrids |
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| Authors: | Lucy Rutten Dr. Birgit Wieczorek Jean‐Paul B. A. Mannie Cornelis A. Kruithof Dr. Harm P. Dijkstra Dr. Maarten R. Egmond Prof. Martin Lutz Dr. Robertus J. M. Klein Gebbink Prof. Piet Gros Prof. Gerard van Koten Prof. |
| Affiliation: | 1. Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands, Fax: (+31)‐30‐2533940;2. Chemical Biology & Organic Chemistry, Debye Institute for Nanomaterials Science, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands, Fax: (+31)‐30‐2523615;3. Membrane Enzymology, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands |
| Abstract: | Crystal‐clear structures : The first crystal structures of organometallic pincer–cutinase hybrids (see figure) provide insight into the 3D structural arrangement of both the protein and the organometallic pincer moiety, and reveal different binding modes for different pincers.  |
| Keywords: | heavy‐metal‐atom labels lipases metalloenzymes pincer– metal complexes X‐ray diffraction |