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Synthesis of a Phosphonate‐Linked Aminoglycoside–Coenzyme A Bisubstrate and Use in Mechanistic Studies of an Enzyme Involved in Aminoglycoside Resistance |
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| Authors: | Feng Gao Dr Xuxu Yan Karine Auclair Prof |
| Institution: | 1. Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montréal, Québec, H3A 2K6 (Canada), Fax: (+1)?514‐398‐3797;2. Currently at Albany Molecular Research Inc. 26 Corporate Circle, P.O. Box 15098, Albany, New York 12212 (USA) |
| Abstract: | Just five steps! The synthesis of a phosphonate‐linked aminoglycoside‐coenzyme A derivative (see scheme) that includes a Michael addition in water has been realized in just five steps.  |
| Keywords: | coenzyme A enzyme inhibitors Michael addition neamine medicinal chemistry |