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Highly Enantioselective Zinc/Amino Alcohol‐Catalyzed Alkynylation of Aldehydes |
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| Authors: | Jiang‐Chun Zhong Dr Shi‐Cong Hou Dr Qing‐Hua Bian Dr Min‐Min Yin Dr Ri‐Song Na Bing Zheng Zhi‐Yuan Li Shang‐Zhong Liu Prof Min Wang Prof |
| Institution: | 1. Department of Applied Chemistry, China Agricultural University, Beijing 100193 (China), Fax: (+86)?10‐62815939;2. Department of Applied Chemistry, China Agricultural University, Beijing 100193 (China), Fax: (+86)?10‐62731070 |
| Abstract: | Meeting the challenge : The zinc/amino alcohol catalyzed enantioselective addition of terminal alkynes to aldehydes is effective with both phenylacetylene and methyl propiolate, leading to chiral secondary propargyl alcohols with very high enantioselectivity (see scheme).  |
| Keywords: | alkynylation amino alcohols asymmetric catalysis zinc |