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Synthesis of Styrenes by Palladium(II)‐Catalyzed Vinylation of Arylboronic Acids and Aryltrifluoroborates by Using Vinyl Acetate |
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| Authors: | Jonas Lindh Jonas Sävmarker Peter Nilsson Dr. Per J. R. Sjöberg Dr. Mats Larhed Prof. |
| Affiliation: | 1. Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, Uppsala University, BMC, Box‐574, SE‐751 23 Uppsala (Sweden);2. Department of Physical and Analytical Chemistry, Uppsala University, BMC, Box‐599, SE‐751 23 Uppsala (Sweden) |
| Abstract: | One Heck of a reaction : Treatment of arylboronic acids or aryltrifluoroborates with vinyl acetate by using a palladium(II) catalyst gives the corresponding styrenes (see scheme). No palladium reoxidant is needed and the vinylation is performed under non‐inert conditions  |
| Keywords: | Heck reaction mass spectrometry mechanistic studies palladium styrene |