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Application of Copper(II)–Dipyridylphosphine Catalyst in the Asymmetric Hydrosilylation of Simple Ketones in Air |
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| Authors: | Xi‐Chang Zhang Yan Wu Feng Yu Fei‐Fei Wu Jing Wu Prof Dr Albert S C Chan Prof Dr |
| Institution: | 1. College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 310036 (P.R. China), Fax: (+86)?571‐2886‐8023;2. Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon (Hong Kong) |
| Abstract: | Ask a copper : A copper(II) salt/chiral dipyridylphosphine/PhSiH3 system (see scheme) acts as a very effective and practical catalyst for the asymmetric reduction of heteroaromatic and other types of ketones in air with good‐to‐excellent enantioselectivities (up to 94 %), giving many chiral alcohols that are intermediates for physiologically active compounds. Remarkable temperature effects were observed for some heteroaromatic ketones.  |
| Keywords: | asymmetric catalysis copper dipyridylphosphine ligands enantioselective hydrosilylation ketones |