1. Department of Chemistry & Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam (The Netherlands), Fax: (+31)?20‐59‐7488;2. Bijvoet Center for Biomolecular Research, Crystal and Structural Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht (The Netherlands)
Abstract:
Diversity‐oriented synthesis : The multicomponent reaction of α‐isocyano amides, aldehydes or ketones, and amines affords N‐(cyanomethyl)amides, presenting the fourth class of products from this combination of reagents (see scheme). The scope of the reaction is very broad and various functional groups are tolerated. The outcome of the reaction can also be directed to the formation of 2H‐2‐imidazolines by AgI catalysis.
