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Highly Enantio‐ and Diastereoselective Organocatalytic Desymmetrization of Prochiral Cyclohexanones by Simple Direct Aldol Reaction Catalyzed by Proline |
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| Authors: | Xavier Companyó Guillem Valero Luis Crovetto Dr. Albert Moyano Prof. Dr. Ramon Rios Dr. |
| Affiliation: | 1. Departament de Química Orgànica, Universitat de Barcelona, Martí i Franquès 1‐11, 08028 Barcelona (Spain), Fax: (+34)?933397878;2. Departamento de Química Física, Facultad de Farmacia, Universidad de Granada, 18071 Granada (Spain);3. ICREA Researcher at UB.;4. ICC Researcher at UB. |
| Abstract: | Panacea for aldol desymmetrizations : We describe an easy entry for the desymmetrization of 4‐substituted‐cyclohexanones catalyzed by proline, using as cocatalysts different hydrogen‐bonding donors (see scheme), which dramatically improves the catalytic efficiency of proline in desymmetrization reactions.  |
| Keywords: | aldol reaction desymmetrization hydrogen bonds organocatalysis proline |