1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022 (China);2. Graduate School of the Chinese Academy of Sciences, Beijing, 100039 (China), Fax: (+86)?431‐85689711;3. Institute of Functional Material Chemistry, Department of Chemistry, Northeast Normal University, Changchun, Jilin, 130024 (China)
Abstract:
Two states, two applications! An Ag+‐mediated DNAzyme switch has been designed to detect Ag+ and cysteine with high sensitivity and selectivity. In the closed state, Ag+ turns on the switch through the formation of cytosine–Ag+–cytosine base pairs, whereas adding cysteine turns off the open switch because it competitively binds to Ag+. This feature endows the DNAzyme switch with two sensing applications.
