Function,expression and localization of annexin A7 in platelets and red blood cells: Insights derived from an annexin A7 mutant mouse期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Function,expression and localization of annexin A7 in platelets and red blood cells: Insights derived from an annexin A7 mutant mouse

Authors:	Claudia?Herr Christoph?S?Clemen Gisela?Lehnert Rüdiger?Kutschkow Susanne?M?Picker Birgit?S?Gathof Carlotta?Zamparelli Michael?Schleicher Email author" target="_blank">Angelika?A?Noegel Email author

Institution:	1.Center for Biochemistry, Medical Faculty,University of Cologne,Cologne,Germany;2.Institute for Clinical Chemistry, Medical Faculty,University of Cologne,Cologne,Germany;3.Transfusion Medicine, Medical Faculty,University of Cologne,Cologne,Germany;4.Centro Biologia Molecolare CNR, Dipartimento di Scienze Biochimiche,Universita La Sapienza,Roma,Italy;5.Institut für Zellbiologie,Ludwig-Maximilians-Universit?t,München,Germany;6.Center for Molecular Medicine,Cologne,Germany

Abstract:	Background Annexin A7 is a Ca²⁺- and phospholipid-binding protein expressed as a 47 and 51 kDa isoform, which is thought to be involved in membrane fusion processes. Recently the 47 kDa isoform has been identified in erythrocytes where it was proposed to be a key component in the process of the Ca²⁺-dependent vesicle release, a process with which red blood cells might protect themselves against an attack by for example complement components.

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