Phosphatase-triggered fusogenic liposomes for cytoplasmic delivery of cell-impermeable compounds |
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| Authors: | J P Michael Motion Juliane Nguyen Francis C Szoka |
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| Institution: | Joint Graduate Group in Bioengineering, University of California, Berkeley, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143-0912 (USA). |
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| Abstract: | License to fuse! A phosphorylated fusion peptide can mediate membrane fusion when the phosphates (green triangles, see scheme) are removed by phosphatases (blue spheres), delivering the contents of the liposome into the cytosol. This phosphatase-triggered approach may be useful to create target-specific lipid nanocarriers. |
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| Keywords: | enzymes fusion peptides liposomes membrane fusion triggered release |
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