5-Acetyl-6-amino-4-methylthio-2-phenylpyrimidine and its use in the synthesis of functionalized pyrido[2,3-d]pyrimidines and pyrimido-[4,5-d]pyrimidines |
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| Authors: | A V Komkov A M Sakharov V S Bogdanov V A Dorokhov |
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| Institution: | (1) N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 117913 Moscow, Russian Federation |
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| Abstract: | Schemes for the synthesis of MeS-substituted pyrido2,3-d]pyrimidin-5-one, pyrimido4,5-d]pyrimidine, and 4-methylenepyrimido4,5-d]pyrimidin-2-one based on 5-acetyl-6-amino-4-methylthio-2-phenylpyrimidine, which was prepared from the adduct of benzoyl isothiocyanate with acetylketeneN-benzoylaminal, were suggested.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1324–1328, July, 1995.The work was carried out with financial support from the Russian Foundation for Basic Research (Grant No. 94-03-08964). |
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| Keywords: | 5-acetyl-6-amino-4-methylthio-2-phenylpyrimidine pyrido[2 3-d]pyrimidin-5-one pyrimido[4 5-d]pyrimidine 4-methylenepyrimido[4 5-d]pyrimidin-2-one acetylketene aminal benzoyl isothiocyanate phenyl isocyanate dimethylformamide dimethylacetal dimethylacetamide dimethylacetal |
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