| 无种子法纳米金棒的制备及其对肿瘤细胞光热治疗效应研究 |
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| 作者单位： | 1. College of Chemistry and Chemical Engineering, University of Yangzhou, Yangzhou 225002, Jiangsu Province, P. R. China;2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, P. R. China |
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| 基金项目： | The project was supported by the National Natural Science Foundation of China (21261130090, 21073047) and Special Fund for Pilot Technology of Chinese Academy of Sciences (XDA09030303). |
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| 摘 要： | 采用简便快捷的无种子法一步完成了纳米金棒的制备.通过改变实验条件可以调控纳米金棒的吸收峰从可见到近红外转移.将巯基聚乙二醇(PEG-SH)置换金棒表面的十六烷基三甲基溴化铵(CTAB)分子,大大提高了金棒的生物相容性.制备的纳米金棒在近红外(NIR)光照射下对肿瘤细胞有很好的杀伤效果.研究结果为纳米金棒用于抗肿瘤治疗提供了实验基础.
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| 关 键 词： | 纳米金棒 等离子共振吸收 生物相容性 表面修饰 热疗 |
| 收稿时间： | 2014-03-17 |
Seedless Synthesis of Gold Nanorods and Applications in Photo-Thermal Cancer Therapy |
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| WANG Xin-Huan,HAN Qiu-Sen,LI Jing-Ying,YANG Rong,DIAO Guo-Wang,WANG Chen. Seedless Synthesis of Gold Nanorods and Applications in Photo-Thermal Cancer Therapy[J]. Acta Physico-Chimica Sinica, 2014, 30(7): 1363-1369. DOI: 10.3866/PKU.WHXB201405063 |
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| Authors: | WANG Xin-Huan HAN Qiu-Sen LI Jing-Ying YANG Rong DIAO Guo-Wang WANG Chen |
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| Affiliation: | 1. College of Chemistry and Chemical Engineering, University of Yangzhou, Yangzhou 225002, Jiangsu Province, P. R. China;2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, P. R. China |
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| Abstract: | We report the synthesis of gold nanorods with a simple and efficient seedless method. By changing the experimental conditions, the longitudinal absorption peak of the gold nanorods can be shifted from the visible to the near-infrared region. Mercaptopolyethylene glycol (PEG-SH) was then used to substitute cetyltrimethyl ammoniumbromide (CTAB) to improve the biocompatibility of the gold nanorods. A strong inhibition of cancer cell growth was observed with the modified gold nanorods under near-infrared (NIR) light irradiation. Our results will be helpful for the potential applications of gold nanorods in clinical photo-thermal cancer therapy. |
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| Keywords: | Gold nanorod Plasmon resonance absorption Biocompatibility Surface functionalization Hyperthermia |
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