Three new lignans, longipedunins A-C, from Kadsura longipedunculata and their inhibitory activity against HIV-1 protease |
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| Authors: | Sun Quan-Zhong Chen Dao-Feng Ding Pei-Lan Ma Chao-Mei Kakuda Hiroko Nakamura Norio Hattori Masao |
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| Affiliation: | Department of Pharmacognosy, School of Pharmacy, Fudan University. |
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| Abstract: | Three new lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and schisanlactone A (6), were isolated from Kadsura longipedunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses. Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC50 values of 50 and 20 microM, respectively. |
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