Common Pharmacophore Model and 3D-QSAR Analysis of Two Different Tyrphostin Families

In the present study we investigated two groups of small molecular tyrosine kinascphosphory lation inhibilors (tyrphostins) with quite different structures (19 compounds of thebenzylidene malononitrile famliy and 13 compounds of the 3-substituted indolin-2-ones family).With the aid of a pharmacophore analysis method (CATALYST). a common three-dimensionalpharmacophore model to these two kinds of molecules has been discovered. A better 3D-QSARanalysis based on the generaled pharmacophore model was conducted (correlate coeffcientR-0.956) and the model shows very good predictivc ability.