生物制剂胸腺肽和转移因子中Zn,Cu,Fe,Mn,Co,Ni的含量分析

胸腺肽和转移因子是临床上常用的两种生物制剂 ,该制剂具有增强机体免疫功能的作用 ,用以治疗免疫缺陷或免疫功能低下、病毒或真菌引起的传染病等。为了探讨微量元素含量与相关疾病之间的关系 ,配合临床上合理使用该种制剂 ,提供生产该类制剂所需此方面的参考数据 ,作者采用原子吸收方法直接检测胸腺肽和转移因子两种生物制剂中Zn ,Cu ,Fe ,Mn ,Co ,Ni六种微量元素的含量。并通过统计学的方法 ,对检测出的各元素含量进行了相关比较。比较结果 :Zn ,Co含量 ,胸腺肽低于转移因子 ;Cu ,Fe,Mn ,Ni含量 ,胸腺肽高于转移因子。两种制剂间 ,Zn ,Cu ,Mn ,Co差异非常显著 (P <0 0 1) ,Fe ,Ni差异显著 (P <0 0 5 )。此结论为临床合理使用生物制剂增强免疫功能 ,在增加或减少制剂中某种微量元素含量方面 ,提供了有用的参考数据。

Analysis of the Contents of Zn,Cu,Fe,Mn,Co and Ni in Thymopeptide and Transfer Factor Biological Injections

Thymopeptide and transfer factor are two common clinic biological preparations, which are used to cure immunodeficiency, low immunofunction or infectious disease caused by virus or fungi owing to their functions of increasing body immunity. In order to discuss the relationship between trace elements and those related diseases, to coordinate sound clinic use of the preparations and to provide productive data on them, atomic absorption spectrophotometry was used to detect the contents of Zn, Cu, Fe, Mn, Co and Ni in thymopeptide and transfer factor biological preparations. Respective contents of detected elements were compared in a statistical way. Results show that Zn and Co contents in thymopeptide were lower than in transfer factor; the contents of Cu, Fe, Mn and Ni, in thymopeptide were higher than in transfer factor. For Zn, Cu, Mn and Co, there was a significant difference between the two biologicam preparations (P<0.01). For Fe and Ni there was a great difference (Q<0.05). The results can provide useful data for sound clinic biological injection to promote immune function, and for increasing or decreasing certain trace elements in preparation.