Structure and in vitro antifungal activity of [2,6‐bis(dimethylaminomethyl)phenyl]diphenyltin(IV) compounds |
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| Authors: | Ale&#x; Ric&#x;ka Libor Dostl Roman Jambor Vladimír Buchta Jir&#x;í Brus Ivana Císar&#x;ov Michal Holc&#x;apek Jaroslav Holec&#x;ek |
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| Institution: | Ale? R??ic?ka,Libor Dostál,Roman Jambor,Vladimír Buchta,Jir?í Brus,Ivana Císar?ová,Michal Holc?apek,Jaroslav Holec?ek |
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| Abstract: | A set of seven 2,6‐bis(dimethylaminomethyl)phenyl]diphenyltin(IV) ({(CH3)2NCH2]2(C6H3)}(C6H5)2Sn+X?) ionic organotin(IV) compounds (X = Br, NO3, CN, SCN, SeCN, BF4 and PF6) has been prepared and characterized by electrospray ionization mass spectrometry, 1H NMR spectroscopy in CDCl3,119Sn NMR in CDCl3 and DMSO‐d6 solution, as well as by 13C and 119Sn CP/MAS NMR spectroscopy and X‐ray diffraction techniques in the solid state. The in vitro antifungal activity of these water‐soluble ionic organotin(IV) compounds was compared with starting compounds and the antifungal drugs currently in clinical use. Copyright © 2002 John Wiley & Sons, Ltd. |
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| Keywords: | water‐soluble organotin(IV) compounds N C N‐ligand NMR spectroscopy CP/MAS NMR spectroscopy X‐ray diffraction ESI mass spectrometry in vitro antifungal screening |
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