细胞表面壳化的研究进展

细胞表面壳化主要是通过物理、化学等技术方法对细胞表面进行修饰,形成完整均匀的有机、无机、金属纳米粒子或者复合壳层结构,从而使不能自身壳化的生物细胞表面形成保护壳甚至赋予细胞新的功能,使细胞具备多功能性。近年来,此技术在细胞存储、细胞运输、细胞传感器、细胞芯片以及细胞治疗等方面应用广泛,发展迅速。本文综合目前的研究现状,详细介绍了可进行细胞表面壳化的细胞类型、生物表面壳化的方法以及人造细胞外壳的工程技术在生物医学以及能源环境中的应用等。

Advances in Cell Surface Shellization

The cell surface shellization is a kind of technology that mainly modifying cell surface to form a complete and uniform organic, inorganic, metal nanoparticles or composite shell structure with physical, chemical and other technical methods. So the cells, which cannot be shellized themselves, can form a protective shell outside and even gain new features, leading to form a multi-functional cell. In recent years, this technology has been widely used in cell storage, cell transportation, cell sensors, cell chips, and cell therapy, and has developed rapidly. This paper synthesizes the current research, and introduces in detail the cell types that can be used for cell surface shellization, the methods of bio-surface shellization, and the application of engineering techniques of artificial cell shells in biomedical and energy environments.