Di‐n‐butyltin aminoarylcarboxylates: structure,properties and in vitro antitumor activity |
| |
| Authors: | Florian P Pruchnik Ma&#x;gorzata Ba&#x;bu&#x;a Zbigniew Ciunik Henryk Chojnacki Ma&#x;gorzata Latocha Barbara Skop Tadeusz Wilczok |
| |
| Institution: | Florian P. Pruchnik,Małgorzata Bańbuła,Zbigniew Ciunik,Henryk Chojnacki,Małgorzata Latocha,Barbara Skop,Tadeusz Wilczok |
| |
| Abstract: | The properties and structures of the tetranuclear dibutyltin complexes Sn4(µ3‐O)2(C4H9‐n)8{OOCC6H3(NH2)2‐3,4}4] (1), Sn4(µ3‐O)2(C4H9‐n)8{OOCC6H3(NH2)2‐3,5}4] (2), Sn4(µ3‐O)2(C4H9‐n)8{OOC‐2‐C6H4N?NC6H4N(CH3)2‐4}4] (3) are described. Complex 3 adopts a structure with a tetranuclear Sn4(µ3‐O)2 core. All tin atoms are five‐coordinate and form bonds with three oxygen atoms and two butyl ligands. Two carboxylates are bridging and two are terminal ligands. IR and NMR spectra indicate that the same structure is adopted by complexes 1 and 2. The molecular and electronic structures of complex 1 of C i symmetry have been studied using the semi‐empirical PM3 formalism. The calculated structure and bond distances agree with X‐ray data. All complexes are effective antitumor agents. Copyright © 2002 John Wiley & Sons, Ltd. |
| |
| Keywords: | organotin complexes antitumor agents crystal structure |
|
|
