| 两个有机锡羟基苯甲酸酯配合物的合成、结构及抗癌活性 |
| |
| 引用本文： | 张复兴,何唐锋,姚淑芬,朱小明,盛良兵,邝代治,冯泳兰,庾江喜,蒋伍玖.两个有机锡羟基苯甲酸酯配合物的合成、结构及抗癌活性[J].无机化学学报,2019,35(4):598-604. |
| |
| 作者姓名： | 张复兴 何唐锋 姚淑芬 朱小明 盛良兵 邝代治 冯泳兰 庾江喜 蒋伍玖 |
| |
| 作者单位： | 衡阳师范学院化学与材料科学学院功能金属有机化合物湖南省重点实验室功能金属有机材料湖南省普通高等学校重点实验室 |
| |
| 基金项目： | 湖南省高校创新平台开放基金项目（No.GN16K01），衡阳市科技计划（No.2016KJ03），湖南省重点学科基金，湖南省高校科技创新团队支持计划和湖南省大学生研究性学习和创新性实验项目资助。 |
| |
| 摘 要： | 合成了2个有机锡羟基苯甲酸酯配合物:梯形结构的二(对氯苄基)锡邻羟基苯甲酸酯(μ_3-O)(μ_2-OH)(p-Cl-C_6H_4CH_2Sn)_2(O_2CC_6H_4-OH-o)]_2(1)和三苯基锡二(对羟基苯甲酸)酯(2)。通过元素分析、红外光谱、差热分析、X射线单晶衍射等方法对配合物进行了结构表征,并对其进行了量子化学从头计算和体外抗癌活性研究。结果显示:配合物1为具有Sn_2O_2构筑的3个平面四元环组成的梯形骨架结构,配合物2为单锡核结构,锡原子均为五配位的畸变三角双锥构型;配合物对人结肠癌细胞(HT-29)、肝癌细胞(HepG2)、乳腺癌细胞(MCF-7)、宫颈癌细胞(Hela)和肺癌细胞(A549)均显示出比临床使用的顺铂更强的抗癌活性。
|
| 关 键 词： | 有机锡羟基苯甲酸酯 晶体结构 量子化学 体外抗肿瘤活性 |
| 收稿时间： | 2018/8/20 0:00:00 |
| 修稿时间： | 2019/1/30 0:00:00 |
Syntheses, Crystal Structures and in Vitro Antitumor Activity of Two Organotin Hydroxybenzoate |
| |
| ZHANG Fu-Xing,HE Tang-Feng,YAO Shu-Fen,ZHU Xiao-Ming,SHENG Liang-Bing,KUANG Dai-Zhi,FENG Yong-Lan,YU Jiang-Xi and JIANG Wu-Jiu.Syntheses, Crystal Structures and in Vitro Antitumor Activity of Two Organotin Hydroxybenzoate[J].Chinese Journal of Inorganic Chemistry,2019,35(4):598-604. |
| |
| Authors: | ZHANG Fu-Xing HE Tang-Feng YAO Shu-Fen ZHU Xiao-Ming SHENG Liang-Bing KUANG Dai-Zhi FENG Yong-Lan YU Jiang-Xi and JIANG Wu-Jiu |
| |
| Institution: | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China,Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China,Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China,Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China,Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China,Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China,Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China,Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China and Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China |
| |
| Abstract: | |
| |
| Keywords: | organotin hydroxybenzoates crystal structure quantum chemistry in vitro antitumor activity |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《无机化学学报》浏览原始摘要信息 |
| 点击此处可从《无机化学学报》下载免费的PDF全文 |
|
