| 3-羟基邻苯二甲酰亚胺全水溶性次氯酸荧光探针及其应用 |
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| 引用本文： | 张春香,刘旭,靳俊玲,申有名,谷标.3-羟基邻苯二甲酰亚胺全水溶性次氯酸荧光探针及其应用[J].分析试验室,2022,41(2):130-134. |
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| 作者姓名： | 张春香 刘旭 靳俊玲 申有名 谷标 |
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| 作者单位： | 洞庭湖生态经济区建设与发展协同创新中心,湖南文理学院化学与工程学院,常德415000,功能金属有机化合物湖南省高校重点实验室,衡阳师范学院化学与材料科学学院,衡阳421008 |
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| 基金项目： | 国家自然科学基金(21907026)；;湖南省自然科学基金(2019JJ50009)；;常德市指导性科技计划项目(2020ZD28)；;湖南文理学院科学研究项目(20YB23)资助； |
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| 摘 要： | 利用二甲基硫代氨基甲酸酯对次氯酸(HOCl)的特异性和吡啶盐的水溶性,以4-羟基异苯并呋喃-1,3-二酮作为原料,设计合成了一种检测HOCl的全水溶性激发态分子内质子转移(ESIPT)荧光探针.由于二甲氨基硫代甲酸酯对羟基的保护,探针分子内的ESIPT作用被阻碍,自身无荧光;当加入HOCl时,HOCl氧化二甲氨基硫代甲...
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| 关 键 词： | 荧光探针 次氯酸 激发态分子内质子转移 细胞成像 |
A 3-hydroxyphthalimide based full water-soluble fluorescent probe for hypochlorous acid and its application |
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| ZHANG Chunxiang,LIU Xu,JIN Junling,SHEN Youming,GU Biao.A 3-hydroxyphthalimide based full water-soluble fluorescent probe for hypochlorous acid and its application[J].Chinese Journal of Analysis Laboratory,2022,41(2):130-134. |
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| Authors: | ZHANG Chunxiang LIU Xu JIN Junling SHEN Youming GU Biao |
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| Institution: | (Hunan Province Cooperative Innovation Center for the Construction&Development of Dongting Lake Ecological Economic Zone,College of Chemistry and Materials Engineering,Hunan University of Arts and Science,Changde 415000;Key Laboratory of Functional Metal-Organic Compounds of Hunan Province,College of Chemistry and Materials Science,Hengyang Normal University,Hengyang 421008) |
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| Abstract: | A full water-soluble excited intramolecular proton transfer(ESIPT)fluorescent probe was constructed by employing dimethylthiocarbamate group as the recognition unit and 4-hydroxy-2-(pyrlin-2-ylmethyl)isoindoline-1,3-dione as the fluorophore.The probe containing pyridinium salt group exhibited preeminent water-solubility and was employed to detect hypochlorous acid(HOCl)in full water solution.The protection of hydroxyl group with dimethylthiocarbamate blocked the ESIPT process,leading to the weak fluorescent of the probe.However,with the addition of HOCl,the dimethylthiocarbamate group was cleaved,releasing the hydroxyl group,leading to the fluorescence appeared due to the recovery of ESIPT process.The probe could detect HOCl in the linear range of 0-80μmol/L with the detection limit of 94 nmol/L.Additionally,the probe displayed fast response(4 min)and large Stokes shift(113 nm),and could be used for detection of HOCl in water samples and living cells. |
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| Keywords: | fluorescent probe hypochlorous acid excited intramolecular proton transfer(ESIPT) cell imaging |
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