| L-cysteine modified gold nanoparticles / paper chip system for rapid detection of chiral dopaEI北大核心CSCD |
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| 引用本文： | 张剑,苗延青,张博,杨玉莹,刘春叶.L-cysteine modified gold nanoparticles / paper chip system for rapid detection of chiral dopaEI北大核心CSCD[J].分析试验室,2022,41(1):66-69. |
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| 作者姓名： | 张剑 苗延青 张博 杨玉莹 刘春叶 |
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| 作者单位： | 西安医学院药学院,西安710021 |
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| 基金项目： | 陕西省科技厅社发一般项目(2021SF-323);陕西省科技厅自然科学基金面上项目(2020JM-614);陕西省教育厅服务地方科学研究计划(19JC035);西安医学院校内人才项目(2018XNRC03);西安医学院博士科研启动基金(2018DOC17)资助。 |
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| 摘 要： | A new detection method for L-Dopa based on paper chips was established. The L-Cys-AuNPs were characterized by their size, zeta potential, and UV-visible absorption spectra. The system had the high selectivity for the colorimetric detection of L-Dopa with the color changing from red to blue. The results were recorded using a common cell phone and subsequently analyzed using Photoshop software. A ratiometric color intensity method was designed for the quantification analysis. The ratio of color intensity at red channel and blue channel (R / B) increases linearly with L-Dopa concentration in the range of 5 to 80 μmol / L (R = 0. 9944), with the limit of detection of 4 μmol / L. The spiked recoveries of samples were 98%-102%. The RSDs of inter-day and intraday were 3. 3% and 3. 8%, respectively. Real samples were detected, and the error between the determination and the labeled value was within 5%. The method can be used to detect L-Dopa in real samples. © 2022, Youke Publishing Co.,Ltd. All rights reserved.
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| 关 键 词： | L-多巴 纳米金 纸芯片 手性识别 |
L-cysteine modified gold nanoparticles/paper chip system for rapid detection of chiral dopa |
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| ZHANG Jian,MIAO Yanqing,ZHANG Bo,YANG Yuying,LIU Chunye.L-cysteine modified gold nanoparticles/paper chip system for rapid detection of chiral dopa[J].Chinese Journal of Analysis Laboratory,2022,41(1):66-69. |
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| Authors: | ZHANG Jian MIAO Yanqing ZHANG Bo YANG Yuying LIU Chunye |
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| Institution: | (School of Pharmacy,Xi'an Medical University,Xi'an 710021) |
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| Abstract: | |
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| Keywords: | L-Dopa gold nanoparticles microfluidic paper-based analytical devices chiral recognition |
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