基于钨酸镍与氧化锌复合材料的电化学传感平台检测吲哚美辛EI北大核心CSCD

采用一锅法制备了钨酸镍与氧化锌复合材料(NiWO_(4)-ZnO),并对其进行了形貌表征、元素分析及比表面积测试,构筑了一种吲哚美辛电化学传感器。研究发现,NiWO_(4)-ZnO复合材料修饰玻碳电极对吲哚美辛表现出较高的检测灵敏度,在最优的实验条件下,吲哚美辛浓度与氧化峰电流成正比,在250~1082 pmol/L范围内呈现良好的线性关系,线性相关系数为0.9970,检出限为66.6 pmol/L。吲哚美辛电化学传感器应用于实际样品中吲哚美辛的测定,回收率为95.1%~98.3%,相对标准偏差为2.3%~3.8%,该传感器可用于药物分析领域。

Electrochemical sensing platform for detection of indometacin using nickel tungstate and zinc oxide composites

The composite material of nickel tungstate and zinc oxide (NiWO4-ZnO) was prepared by one-pot synthesis, and morphology characterization, elemental analysis, and specific surface area tests were carried out. The electrochemical sensor based on the composite was applied to detect indometacin(INDO). Under the optimal experimental conditions, the oxidation peak current increased with the increase of INDO concentration, and a good linear relationship was observed in the range of 250-1082 pmol / L(R = 0. 9970), with a detection limit of 66. 6 pmol / L. The fabricated sensor showed excellent sensitivity, stability, and reproducibility. This simple, fast, and low-cost strategy was successfully applied to the analysis of practical samples. The recoveries and the relative standard deviations were 95. 1%-98. 3% and 2. 3%-3. 8%, respectively, indicating the potential of this method for medicine analysis. © 2022, Youke Publishing Co., Ltd. All rights reserved.